The group are seen performing the track in front of a backdrop of flashing lights in the clip, which they released online yesterday (August 28).
The track is available to download in the US now, while a UK date is yet to be confirmed.
'Feel Again' was inspired by the heartbeats of children in remote American villages who are in need of life-saving care. A portion of the proceeds from the song will go towards charity Save The Children.
The number is the first from OneRepublic's upcoming third studio album, which is due for release later this year.
The LP follows 2009's Waking Up, which spawned the singles 'All The Right Moves' and 'Secrets'.
OneRepublic are scheduled to play this year's iTunes festival in London alongside Ellie Goulding on September 26.