The original Sugababes lineup said that they are unlikely to work with the group unless it was for charity.
Asked if they would team up with Girls Aloud for the next Comic Relief single, Mutya Buena told Popjustice: "Why not? I love Girls Aloud. I've always liked the girls."
Keisha Buchanan added: "That would be a good thing," while Siobhan Donaghy noted: "And we're so different that I actually think we'd complement each other."
On whether they'd work with the band outside of a charity effort, Buena confessed: "We'd say no, but there's no hate in it."
Buchanan previously collaborated with Girls Aloud for Comic Relief in 2007 under the third Sugababes lineup, where they covered Aerosmith's 'Walk This Way'.
Mutya Keisha Siobhan recently confirmed plans to release new music this year.
Watch Mutya Keisha Siobhan perform 'One Touch' below: