The girl group's first single proper 'Wings' takes the helm on this week's list, while Of Monsters and Men slip to two with 'Little Talks'.
Rita Ora is at three with 'How We Do (Party)', Lykke Li moves up to four with 'I Follow Rivers', and Florence + the Machine are at five with 'Spectrum'.
Sam and the Womp's 'Bom Bom' vaults up to number six, Lucy Spraggan's X Factor audition track 'Last Night' lands at 16, and Cheryl's 'Under the Sun' advances to 20.
Public Enemy's 'Harder Than You Think' is up to 23, Cover Drive are at 27 with 'Explode', and Maroon 5's 'One More Night' is at 36.
This week's Irish Top 10 is as follows:
1. (-) Little Mix: 'Wings'
2. (1) Of Monsters and Men: 'Little Talks'
3. (2) Rita Ora: 'How We Do (Party)'
4. (8) Lykke Li: 'I Follow Rivers'
5. (3) Florence + the Machine: 'Spectrum (Say My Name)'
6. (22) Sam and the Womp: 'Bom Bom'
7. (12) fun.: 'Some Nights'
8. (7) Owl City and Carly Rae Jepsen: 'Good Time'
9. (4) Taylor Swift: 'We Are Never Ever Getting Back Together'
10. (11) Wiley: 'Heatwave'
Watch the music video for Little Mix's 'Wings' below: