The singer's latest track charged to the top of the iTunes tally within hours of its release yesterday (September 2).
The song knocked off Little Mix, who landed their second number one on the Official Singles Chart last week with 'Wings'.
'Blow Me (One Last Kiss)' is competing with The Script and will.i.am's collaboration 'Hall Of Fame', which currently sits at number two, while Ne-Yo's 'Let Me Love You (Until You Learn To Love Yourself)' enters at three.
Pink's new track serves as the lead single from her sixth studio album The Truth About Love, which is out on September 17.
The LP follows 2008's Funhouse, which topped the charts in the UK and sold over six million copies worldwide.
The star recently revealed that fans of Chris Brown sent her death threats over Twitter after she made a joke about the singer.
Watch the 'Blow Me (One Last Kiss)' music video below: