The 'Call Me Maybe' singer faces tough competition in the 'Best New Artist' category against fellow chart-toppers One Direction, Frank Ocean, 'Glad You Came' band The Wanted and fun.
In an interview with MTV News, Owl City - real name Adam Young - suggested that his 'Good Times' collaborator deserves the prize.
"[Her chances are] pretty good. They're all good, but I'm rooting for her," Owl City declared.
He went on to say that he truly respects Jepsen for her kindness as well as her musical talent.
"It's sincerity. She's genuine. I don't know what it is," he said. "The song ['Call Me Maybe'] is really catchy, but she is really amazing. She fits that song."
Jepsen's mentor Justin Bieber famously took the MTV Video Music Award for 'Best New Artist' in 2010 for his music video 'Baby'.
Eurythmics, Nirvana, Eminem, Avril Lavigne, The Killers and Lady GaGa have also won the award in the last 28 years.
Kevin Hart hosts the 2012 MTV Video Music Awards, airing live from the Staples Centre in Los Angeles on Thursday, September 6 at 8/7c.
> MTV VMA poll: Who should win 'Best New Artist'?
> MTV Video Music Awards 2012: The nominees in full
Watch Carly Rae Jepsen's 'Call Me Maybe' music video below: