The rapper has teamed up with Lil Wayne for new cut 'Mercy', which will feature on his upcoming mixtape Dedication 4.
"I'm a Republican voting for Mitt Romney/You lazy bitches is f**king up the economy," Minaj raps.
Minaj challenged President Barack Obama earlier this year over his healthcare reform after US actress Yvette Wilson died from cervical cancer while trying to raise money for medical costs.
"What's sad is that when Yvette was bringing home the bacon, the gov't was probably taking millions. On her deathbed though, #Nowheretobefound," she wrote at the time.
"That should be a God given right! Even with Obama Care, too much involved. Just give FREE health care to all. @BarackObama what can we do?"
She later added: "@BarackObama I wouldn't mind the millions they took if it was going to healthcare. Why should a poor person struggle to pay for MEDS sir?"
Lil Wayne and Nicki Minaj's 'Mercy' is a reworking of Kanye West's recent track of the same name and is available as a free download.
Listen to Lil Wayne and Nicki Minaj's 'Mercy' below: