The Australian DJ will put out her RedOne-produced track 'We Run the Night' on October 8.
Discussing the song, she said: "I wanted to combine the club and commercial worlds in one song.
"I wanted to make something that I could play in my DJ sets and on my radio show… RedOne was perfect. We were trying to mix two types of music together."
The track - which has had over 18 million hits on YouTube - has already entered the charts all over the world, peaking at number five in Australia and number 26 on the Billboard Hot 100.
Brown, who started her DJ career in 2006, has supported The Pussycat Dolls, Lady GaGa and Britney Spears on the Australian legs of their world tours.
Watch the 'We Run the Night' music video below: