The Irish band fronted by Danny O'Donoghue remain at the singles helm with 'Hall Of Fame', fending off competition from Example's 'Say Nothing', which is at two.
Ne-Yo remains at number three with 'Let Me Love You', Pink advances to four with 'Blow Me (One Last Kiss)' and Taylor Swift is up to five with 'We Are Never Ever Getting Back Together'.
Dappy lands at eight with 'Good Intentions', while internet sensation Psy vaults up to 16 with his viral hit 'Gangnam Style'.
The Only Way Is Essex star Jessica Wright enters at number 27 with her debut single 'Dance All Night' and Justin Bieber's 'As Long As You Love Me' moves up to 32.
Over on the album chart, The Killers lead the list with their fourth outing Battle Born.
The Nevada band are currently 9,000 copies ahead of Pink's sixth studio collection The Truth About Love, which is at two.
Elsewhere, Michael Jackson's repackaged 1987 album Bad is at six, Carly Rae Jepsen is at eight with Kiss and Nelly Furtado's Spirit Indestructible is currently at number 34.
Watch the music video for The Killers' 'Runaways' below: