A host of the world's biggest DJ acts will play at Playa del Carmen in Mexico on December 20-21, 2012 to coincide with the planets aligning.
The event - which is being organised by Crosstown Rebels - will mark the end-date of a 25,625-year-long cycle and fifth and final cycle of the Mesoamerican Long Count calendar.
Massive Attack's Robert '3D' Del Naja will perform alongside UNKLE's James Lavelle to include live recreations and re-workings of Massive Attack's music.
Danish DJ Trentemøller, Jamie Jones, Subb-an, Metrika, Acid Pauli, Francesca Lombardo and Amirali are among the other acts booked to perform.
Day Zero will take place on a pyramid site set between two lakes in Playa del Carmen, the centre of Mayan civilisation.
"This is a phenomenal moment in time and there is no way we could let it pass without hosting an amazing and unforgettable celebration," Crosstown Rebels founder Damian Lazarus said.
"It's going to be a moment that our generation can latch on to that actually feels credible, poignant and special."
Tickets are priced at $40 (£24) and are on sale now. For more information visit the official Day Zero website.