The rapper has teamed up with The Weeknd for new cut 'Remember You', which has been lifted from his forthcoming album O.N.I.F.C.
The track is available to download in the US now and is expected to be released in the UK in the coming months.
'Remember You' serves as the follow-up to lead single 'Work Hard, Play Hard', which was released back in April.
50 Cent, 2 Chainz, Pharrell Williams, Mac Miller and fiancé Amber Rose are among artists expected to feature on the new collection, which will be released on December 3 in the UK and a day later in the US.
Meanwhile, The Weeknd - real name Abel Tesfaye - recently confirmed plans to release his debut album titled Trilogy, which will include cuts from his three mixtapes along with new material.
Listen to Wiz Khalifa and The Weeknd's 'Remember You' below: