The girl group will release 'DNA' as the second original single to be lifted from their debut album of the same name.
The track will be served to UK radio on Monday, October 1 at 8am, according to radio station In:Demand.
'DNA' has been described as an "electro ballad" that is "very cool" and has "big vocals".
The single will be available to download in the UK from November 12, while Little Mix's debut album DNA follows on November 19.
Meanwhile, the group are rumoured to have collaborated with TLC star T-Boz for a new track titled 'Red Planet'.
Watch the music video for Little Mix's recent chart-topping hit 'Wings' below: