The supermodel has signed up to front the annual ceremony in November in Frankfurt.
"I'm honoured to host the 2012 MTV EMAs in its return to my home country of Germany," said Klum.
"The MTV EMAs is one of the biggest nights in global music, fashion and culture, and I'm thrilled to play a part in bringing this one-of-a-kind show to audiences all over the world. We're going to have a blast!"
Rihanna and Taylor Swift lead the awards with six and five nominations respectively. Justin Bieber and Katy Perry follow them up with four nominations each.
The performers and presenters on the show are yet to be announced.
Klum is currently considering suing a French publication for printing topless photos of her following a court's decision to grant an injunction to the Duchess of Cambridge against Closer.
The 2012 MTV Europe Music Awards will take place at the Festhalle in Frankfurt on Sunday, November 11 from 9pm local time, and will be broadcast on MTV channels around the world.
Photo gallery - Full list of MTV Europe Music Awards 2012 nominees:
Copyright: PA Images Chris Pizzello/AP