The 'Drunk on You' singer has earned seven nominations in all, including 'Artist of the Year' and 'Album of the Year' for Tailgates and Tanlines.
Lady Antebellum and the Zac Brown Band are runners-up with six nods each, with Taylor Swift and Erich Church also recognised in multiple categories.
The night's most prestigious award 'Artist of the Year' pits Bryan against fellow country music heavy-hitters Jason Aldean, Lady Antebellum, Taylor Swift and the Zac Brown Band.
Fans are invited to vote for the American Country Awards on its official website.
This year's awards ceremony will be hosted by Trace Adkins and Kristin Chenoweth for the second year in a row. Adkins previously hosted solo in 2010.
The 2012 American Country Awards air live from Mandalay Bay in Las Vegas on Monday, December 10 on Fox.
> American Country Awards 2012: The nominees in full
Watch Luke Bryan's 'Drunk on You' music video below: