The pair have teamed up for 'Beauty and a Beat', which is the third official single to be lifted from the Canadian star's latest album Believe.
The collection reached number one on both the UK and US charts back in June and has sold over a million copies Stateside.
'Beauty and a Beat' was co-written by Max Martin, Anton Zaslavski, Savan Kotecha and Nicki Minaj.
It is due to receive its official release on November 12, but is available to download on iTunes now.
Meanwhile, Justin Bieber's manager Scooter Braun has hinted at plans for the star to record a new acoustic album in the future.
Listen to Justin Bieber and Nicki Minaj's 'Beauty and a Beat' below: