The singer's new cut 'Skyfall' leads this week's tally, while Swedish House Mafia trail at two with 'Don't You Worry Child'.
Psy's 'Gangnam Style' is at three, Rihanna's 'Diamonds' is at four and Lykke Li slips to five with 'I Follow Rivers'.
One Direction tumble to six with 'Live While We're Young', while Conor Maynard's 'Turn Around' advances seven places to 14.
Leona Lewis lands at 21 with new single 'Trouble', while Taylor Swift's latest promotional cut 'I Knew You Were Trouble' debuts at 29.
Elsewhere, Kelly Clarkson's 'Stronger' re-enters the chart at 36, while Bruno Mars's new single 'Locked Out of Heaven' premieres at 37.
This week's Irish Top 10 is as follows:
1. (-) Adele: 'Skyfall'
2. (-) Swedish House Mafia: 'Don't You Worry Child'
3. (2) Psy: 'Gangnam Style'
4. (5) Rihanna: 'Diamonds'
5. (4) Lykke Li: 'I Follow Rivers'
6. (1) One Direction: 'Live While We're Young'
7. (3) The Script ft. will.i.am: 'Hall of Fame'
8. (6) Of Monsters and Men: 'Little Talks'
9. (11) David Guetta ft. Sia: 'She Wolf (Falling to Pieces)'
10. (7) Mumford & Sons: 'I Will Wait'
Listen to Adele's 'Skyfall' below: