The band will release 'Six Degrees of Separation' on November 25 as the second cut to be lifted from their recent album #3.
The track serves as the follow-up to 'Hall of Fame', which featured will.i.am and topped the UK singles chart last month.
'Six Degrees of Separation' was written by band members Danny O'Donoghue, Mark Sheehan and Glen Power and was recorded at Sphere Studios in London.
It was produced by O'Donoghue and Sheehan, along with fellow Irish producer Jimbo Barry.
The Script will embark on a headline arena tour of the UK in 2013, which starts at Belfast's Odyssey Arena on March 4.
Listen to The Script's new single 'Six Degrees of Separation' below: