The boyband were voted the 'Best UK and Ireland Act' ahead of the show on November 11 and will be presented with the award during the event in Frankfurt.
One Direction received the most votes from fans to win the accolade and will now compete against winners from other European countries for the 'Best Worldwide Act' award.
"We're so happy and incredibly honoured to have won this," said Louis Tomlinson. "Once again our amazing fans have done us proud - thanks so much as always to you all!"
One Direction will also compete in the 'Best New Act' and 'Biggest Fans' categories at next month's ceremony.
The group's second studio album Take Me Home will be released in the UK on November 12 and a day later in the US.
Watch the music video for One Direction's 'Live While We're Young' below: