The 'Oh Love' band cancelled their October 27 headlining slot at the New Orleans concert series due to singer Billie Joe Armstrong entering rehab.
Lars Ulrich has now confirmed in a press statement that Metallica have decided to step in for Green Day at the Voodoo Music + Arts Experience.
"Our good friends and fellow Bay Area residents Green Day had to unfortunately cancel their plans to be there, so we are more than happy to fill in for them in our own unique way," Ulrich explained.
He added: "We're hoping we can fill those very large shoes and do them proud."
The gig will mark Metallica's first appearance at the annual New Orleans festival.
Green Day's Armstrong entered a treatment centre on September 23 after an on-stage meltdown at the iHeartRadio Music Festival, in which he publicly complained about the band's set being cut short.
"I'm not Justin Bieber, you motherf**kers! You gotta be f**king joking," Armstrong shouted from the stage.
Last month, Green Day released ¡Uno!, their first in a trio of new albums. Two additional records, ¡Dos! and ¡Tré!, are released in the next few months.
Watch Green Day's 'Oh Love' music video below: