The retrospective - called Chapter One - features 17 tracks including her hit singles 'Since U Been Gone', 'My Life Would Suck Without You' and 'Stronger'. The cover appears below:
Clarkson recently unveiled new track 'Catch My Breath' ahead of the LP's release, which is available to download on November 18.
Discussing the track, she said: "This song represents who I've been, what I've felt, and where I'm headed as not only an artist but as a 30-year-old that is now smart enough to know that it's time to stop, catch my breath, and be proud of not only what has been accomplished but of all the people that have helped me become the woman I am today."
The star has released five albums to date and has sold over 20 million records worldwide.
Her most successful record is 2004's Breakaway, which has sold 12 million copies worldwide, with 1.5 million in the UK alone.
Greatest Hits - Chapter One is out November 19 in the US and November 26 in the UK. The tracklisting appears below:
1. Since U Been Gone
2. My Life Would Suck Without You
3. Miss Independent
4. Stronger (What Doesn't Kill You)
5. Behind These Hazel Eyes
6. Because Of You
7. Never Again
8. Already Gone
9. Mr. Know It All
11. Don't You Wanna Stay (with Jason Aldean)
12. Walk Away
13. Catch My Breath
14. People Like Us
15. Don't Rush (featuring Vince Gill)
16. A Moment Like This
17. I'll Be Home For Christmas
Listen to 'Catch My Breath' below: