Sandé picked up a prize for this year's 'Best Solo Artist' - beating Adele, Noel Gallagher and Florence + the Machine - while Blur won the gong for 'Best Live Act' over Radiohead and The Stone Roses.
Gallery: Q Awards 2012 arrivals
Copyright: PA Images Dominic Lipinski/PA Wire
Other winners included Django Django for 'Best New Act', Plan B's 'iLL Manors' for 'Best Track' and Muse for 'Best Act In The World Today'.
Q Magazine Editor Andrew Harrison said in a statement: "It's been the most incredible year for British music.
"Our bands and our anthems transformed the Olympics. A string of great albums announced fantastic new talent on the scene. And amazing comeback shows from Blur and the Stone Roses showed the enduring appeal of our best-loved musicians.
"Q is proud to raise a glass (perhaps a bottle of our very own Q Red Label Beer) to salute the artists that make Britain the world capital of rock and roll."
The Inspiration Award was given to Pulp, the 'Innovation In Sound' prize was awarded to Underworld, and Q's 'Classic Song' was given to Dionne Warwick's 'Walk On By'.
The full list of this year's Q Award winners appears below:
Q Best New Act Presented By Merc
Django Django - WINNER
Lianne La Havas
Florence + the Machine - 'Shake It Out'
Fun - 'We Are Young'
Gotye - 'Somebody That I Used To Know'
Plan B - 'Ill Manors' - WINNER
Rizzle Kicks - 'Mama Do The Hump'
Best Album Presented By Red Stag by Jim Beam
The Black Keys - El Camino
Richard Hawley - Standing At The Sky's Edge
The Maccabees - Given To The Wild
Paul Weller - Sonik Kicks
Bobby Womack - The Bravest Man In The Universe - WINNER
Best Live Act
Blur - WINNER
The Stone Roses
Arctic Monkeys - 'R U Mine?'
Noel Gallagher's High Flying Birds - 'Everybody's On The Run'
Keane - 'Disconnected' - WINNER
The Killers - 'Runaways'
Nicki Minaj - 'Starships'
Best Solo Artist presented by Citroen
Emeli Sandé - WINNER
Best Act In The World Today
Muse - WINNER
The Stone Roses
Q Classic Song
Dionne Warwick: 'Walk On By'
Q Spirit Of Independence
Q Innovation In Sound
Q Inspiration Award
Q Icon Award
Q Classic Album
Manic Street Preachers: Generation Terrorists