The iconic band are charging between £106 and £406 for their O2 Arena gig in London next month, and Muse have insisted that they would never make their fans pay that much.
"We've always tried to keep prices as low as we can so people can come and watch us," Christopher Wolstenholme told the Daily Star.
"What's reasonable for one person isn't reasonable to another, but there really is only so much money a band needs."
He added: "It's important to make some money but we don't always break even because the most important thing is to go out and play live.
"We could earn more if we wanted to by cutting production costs, but it's not about that."
Muse will begin the UK leg of their upcoming European tour at Glasgow's SECC on October 24.
The jaunt is in support of their recent album The 2nd Law, which topped the UK chart and reached number two on the US Billboard 200 earlier this month.
Watch the music video for Muse's recent single 'Madness' below: