More artists have been announced for the free event that will be held in London, Manchester, Liverpool and Birmingham on four consecutive nights.
Tulisa and Trey Songz, who have already been announced for the London leg of the event at Brixton Academy on Monday, November 12, will be joined by Kendrick Lamar, Wizkid and Angel.
Grime MC Wiley, X Factor contestant Misha B, Daley, DJ Fresh and Rita Ora will feature at the Manchester Apollo event on Tuesday, November 13.
The next evening will see Rudimental and Devlin joining Plan B and Labrinth at the Liverpool Echo Arena.
The final night will be held on Thursday, November 15 at the Birmingham Ballroom, where Keys will appear alongside Disclosure and Miguel.
1Xtra presenters MistaJam, Trevor Nelson, Charlie Sloth, Sarah-Jane Crawford, Twin B, Adele Roberts and Yasmin Evans will be hosting the events, which will also showcase a variety of local talent.
BBC Radio 1Xtra Live 2012 marks the event's fifth consecutive year.
The event will be simulcast live on BBC Radio 1 and 1Xtra and streamed online at bbc.co.uk/1xtra. The Wednesday and Thursday shows will be also broadcast on the red button from 7pm to 11pm.
Tickets for the 1Xtra Live tour are free (plus handling fee) and will be available every day from 9am between October 29 and November 1 via online and telephone booking.