The crooner plays the residency in June and July 2013, marking the third-longest run of dates at the venue for a male solo artist behind Prince and Roger Waters.
The shows are Bublé's first concerts in the country since his 20-date arena and stadium tour in 2010.
Tickets go on sale next Friday, November 2 at 9am and are priced at £45.00 / £55.00 / £70.00.
Bublé releases a deluxe edition of his Christmas on November 19.
Packaged in silver foil, the new edition includes Bublé's Christmas greeting and adds bonus tracks 'The Christmas Song', 'Winter Wonderland', 'Frosty The Snowman' (featuring The Puppini Sisters) and 'Silver Bells' (featuring Naturally 7).
The dates of Michael Bublé's O2 residency are as follows: June 30, July 1, July 3, July 4, July 5, July 7.
Watch the Michael Bublé O2 residency trailer below