The female rapper picked up a prize for 'Best Video' for 'Bad Girls', while Sean was awarded 'Best Male' as well as the prestigious 'British Artist of the Decade'.
The evening's biggest winner was Rahat Fateh Ali Khan, who took home three awards for 'Best-Selling Download', 'Best International Act' and 'Best International Act of the Decade'.
Prizes also went to singer and actress Preeya Kalidas for 'Best Female', Arjun for 'Best Urban Act' and Yo Yo Honey Singh's International Villager for 'Best International Album'.
The event was hosted by BBC Asian Network's Tommy Sandhu and Radio 1Xtra's Sarah-Jane Crawford and included performances by Arjun, Amanjot Sangha and Imran Khan.
The full winners list for the Asian Music Awards 2012 appears below:
Lebara Mobile Best Club DJ - Panjabi Hit Squad
Nokia Unsigned - Amanjot Sangha
Infusion Best Alternative Act - Raghu Dixit
Kingfisher Best Radio Show - Neev, Kiss 100
Best-Selling Download in association with Official Charts Company - Rahat Fateh Ali Khan 'Teri Meri'
Lebara Money Best International Album - Yo Yo Honey Singh 'International Villager'
Nokia Best International Act - Rahat Fateh Ali Khan
Here & Now 365 Best Producer - Dr Zeus
Lebara Mobile Best Album - JK 'Gabru Panjab Dha'
Saavn Best Desi Act - RDB
B4U Best Video - MIA 'Bad Girls'
Lebara Mobile British Artist of the Decade - Jay Sean
Lebara Mobile International Artist of the Decade - Rahat Fateh Ali Khan
Best Urban Act in association with MOBO - Arjun
Hilton London Wembley Best Newcomer - Shide Boss
Asian Woman Best Female - Preeya Kalidas
Lebara Mobile Best Male - Jay Sean
B4U Commitment to the Scene - RDB
Watch the music video for MIA's 'Bad Girls' below: