The 'Read All About It' star picked up three gongs at the event in Liverpool tonight (November 3) - 'Best Album' for Our Version of Events, 'Best Female' and 'Best R&B/Soul'.
Rapper Plan B also triumphed, a few days after losing out on the Mercury Music Prize, in the 'Best Male' and 'Best Hip-Hop/Grime' categories, while Rita Ora picked up the 'Best Newcomer' prize.
Boyband JLS scooped the 'Best Video' award for their clip for 'Do You Feel What I Feel?', and Labrinth won the 'Best Song' accolade for 'Earthquake', his collaboration with Tinie Tempah.
Other winners included Nicki Minaj for 'Best International Act', Sean Paul and jazz star Zoe Rahman.
The surviving members of girl group TLC also attended the ceremony to collect their 'Outstanding Contribution to Music' award, and pop legend Dionne Warwick was given the 'Lifetime Achievement' honour.
Photo gallery - 2012 MOBO Awards red carpet arrivals and winners:
Copyright: Matt Crossick/EMPICS Entertainment