The Sex and the City actress and the Playing for Keeps star will honour this year's Nobel Peace Prize recipient the European Union on December 11.
Parker and Butler follow on from previous Nobel Peace Prize Concert hosts Liam Neeson, Meryl Streep, Tom Cruise, Oprah Winfrey and last year's presenters Helen Mirren and Rosario Dawson.
Seal and Jennifer Hudson were previously announced as the headlining musical acts for the 19th annual event.
The European Union is receiving this year's Nobel Peace Prize for promoting peace and human rights around the globe.
2012's Nobel Peace Prize Concert is to be held in Oslo, Norway.