The musician insisted that he struggles to enjoy the star's music because there is no substance to "sink your teeth into".
"I don't think she lives it because it's all artifice. It's all image with no meaning behind it," White told Esquire magazine.
"You can't sink your teeth into it. It's a sound bite. It's very of this age, because that's what people want. They want a Twitter line, a jpeg, an MP3."
Photo gallery - GaGa's maddest moments so far:
Copyright: Rex Features Ken McKay/TalkbackThames/Rex FeaturesWhite continued to criticise the rise of celebrity culture, saying: "The goal of modern celebrity is to make yourself into the lowest common denominator.
"'Hey, I'm a guy just like you. I like a beer, a football game'. Especially in reality television, you'll see people will go so far as to make a fool out of themselves just to prove that."
He added: "Twitter is the most perfect example of modern living. I think the only people who should have [Twitter accounts] are comedians. Because it's all about one-liners."
Watch the music video for Jack White's 'I'm Shakin'' below: