The gigs will showcase the duo's first stage production since the 'Pandemonium' tour, which began in 2009 and was performed around the world.
Pet Shop Boys will play London's O2 Arena on June 18 and Manchester Arena on June 20, with European and US dates expected to be announced soon.
They will work with Stuart Price (Madonna, The Killers) on the music, Es Devlin (Lady GaGa, Kanye West & Jay Z) on the set and Lynne Page on choreography.
The show will feature songs from across Pet Shop Boys' entire back catalogue, up to their current album Elysium.
Tickets go on sale at 9am on Saturday, December 8 priced at £30 in Manchester and £35 in London (plus booking fee).
Watch the video for Pet Shop Boys' 'Leaving' below: