The singer, who took part in the charity single alongside stars like Robbie Williams and Sir Paul McCartney, described the track as "incredible" to Capital FM.
The 'When She Was Mine' singer said that it was an "absolute honour" to work with some of his musical heroes on the track.
"I'm just delighted to be involved. I mean I'm singing alongside some of my idols like Paul McCartney and Robbie Williams," he explained.
"The song's incredible itself, 'He Ain't Heavy, He's My Brother', it's got a great meaning behind the song and I really think it deserves to be Christmas number one this year."
The track has been released to support the families of the 96 victims of the Hillsborough disaster in 1989.
Brown, who is originally from Liverpool, sings the opening line of the Hollies cover.
He added: "I mean the fact that I'm opening it is just an absolute honour and a dream come true for me being a Liverpool fan and also born and raised in Liverpool."
The Justice Collective are currently beating James Arthur's 'Impossible' to the festive top spot according to the midweek chart update. It was revealed yesterday that the single was 14,000 copies ahead of Arthur in sales.
The full Christmas chart will be revealed on Sunday (December 23).
Watch the music video for 'He Ain't Heavy, He's My Brother' below: