The Mirage hotel will host the R&B group beginning on March 1 at the Terry Fator Theatre, according to The AP.
The band is expected to perform a total of 78 concerts featuring many of their greatest hits.
Tickets can now be purchased for Boyz II Men's Las Vegas residency through Ticketmaster.
Boyz II Men have sold more than 28 million albums worldwide throughout their 21-year history.
Their biggest hits include the US number one singles 'End of the Road', 'I'll Make Love To You', 'On Bended Knee' and '4 Seasons of Loneliness'.
Watch Boyz II Men perform 'End of the Road' below: