The 'Heaven' singer is recognised in four categories, for 'Best British Female', 'Best British Album' and two entries for 'Best British Single'.
Mumford and Sons, Rita Ora and Mercury Prize winners Alt-J are nominated for three prizes each.
Muse, Paloma Faith, Plan B and Jessie Ware are up for two awards at the 2013 event.
Amy Winehouse has also become the first artist to receive a posthumous nomination for 'Best British Female'.
> Brit Awards 2013: Nominations in full
"It's a really good feeling," Sandé said of her Brit Awards nominations. "It feels great, a bit scary, because you never know, you might not win anything.
"It feels great to have this acknowledgement and recognition. And to come back here after winning the Critics' Choice and to be nominated is really, really cool."
Sandé faces competition in the coveted 'Best British Album' category for her debut release Our Version of Events against Alt-J's award-winning An Awesome Wave, Babel by Mumford and Sons, Paloma Faith's Fall To Grace and Plan B's soundtrack to his film iLL Manors.
Plan B is also nominated for 'Best British Male' against Calvin Harris, Olly Murs, Richard Hawley and Ben Howard.
Emeli Sandé will take on Paloma Faith, Bat For Lashes, Jessie Ware and Winehouse in the 'Best British Female' category.
One Direction are nominated for 'Best British Group', along with Mumford and Sons, Muse, Alt-J and The xx.
Robbie Williams, Adele, X Factor winner James Arthur, and Coldplay are among the acts nominated for 'Best British Single'.
Mumford and Sons, Robbie Williams, Emeli Sandé, Muse, Ben Howard and One Direction will be among the performers at the ceremony next month.
The 2013 Brit Awards will be held at London's O2 Arena on February 20.
Brit Awards 2013 nominees in pictures: