The global competition is on the search for new talent to win music equipment and gear valued at $10,000 (£6,197), as well as shoot a music video and embark on a world tour.
Bands can register on one of Hard Rock Café's 96 participating Facebook pages, where fans get to decide who can move on to the live performance rounds. Registration ends January 21.
Once the favourites have been selected, participating Hard Rock Cafés around the world will host a series of live competitions featuring the voted local bands.
The winners will be narrowed down to a Top 25 and a panel of judges - including Steven Van Zandt of the E Street Band - will decide on a winner.
"Hard Rock is eager to uncover another pool of budding talent and provide them with an international stage to showcase their talents," said John Kirkpatrick, Head of Music & Artist Relations, Hard Rock International.
"More than 12,000 bands entered Hard Rock Rising and nearly one million votes were cast by fans around the globe in 2012 - we hope the continued success of this programme will catapult an emerging band to success and introduce their sound to Hard Rock's worldwide audience."
The winner will play a world tour in cities including Sydney, Tokyo, Hong Kong, London, Chicago and Honolulu, arranged by Hard Rock International, as well as record an album with Hard Rock Records.