Old Sock will be the follow-up to 2010's Clapton and will feature two original tracks alongside a collection of covers.
Sir Paul McCartney and Clapton's former Blind Faith bandmate Steve Winwood will feature on the LP.
'Every Little' and 'Gotta Get Over' will serve as two brand new tracks, while there are 10 cover versions of some of Clapton's favourite songs.
JJ Cale provides backing vocals and guitar on 'Angel', while Chaka Khan sings back-up on 'Get On Over'.
McCartney plays bass and sings on 'All of Me', with Winwood playing organ on 'Still Got the Blues'.
Clapton also covers Leadbelly's 'Goodnight Irene' and Peter Tosh's 'Till Your Well Runs Dry' among others.
The guitarist will support the album with a US arena tour in the spring, concluding at his Crossroads Guitar Festival at Madison Square Garden.
John Mayer, the Allman Brothers Band and Jeff Beck are among the artists performing at this year's festival.
Eric Clapton recently provided guitar on Paul McCartney's latest album Kisses on the Bottom.
Watch Eric Clapton perform 'Crossroads' at the Sandy Relief concert last month below: