The 55th annual Grammy Awards are being held on Sunday (February 10) at the Staples Centre in Los Angeles with an all-star grouping of presenters and performers.
Joining Depp and DeGeneres to give away the prestigious music awards will be Kat Dennings, John Mayer, Pitbull, Bonnie Raitt and Kelly Rowland of the recently reunited Destiny's Child.
Previously announced presenters for the music industry's biggest night are Katy Perry, Neil Patrick Harris, Carly Rae Jepsen, Keith Urban, Faith Hill and Kaley Cuoco.
Sunday's Grammy Awards will also feature live performances from Rihanna, Carrie Underwood, Alicia Keys and Maroon 5, Elton John and Ed Sheeran, Taylor Swift and Justin Timberlake.
The Black Keys will additionally be a part of a special collaboration with the Preservation Hall Jazz Band, Dr John, Stanley Clarke, Kenny Garrett and Chick Corea.
LL Cool J hosts the 55th annual Grammy Awards, airing on Sunday at 8/7c.
Watch Grammys performer Justin Timberlake's 'Suit & Tie' lyric video below: