The Los Angeles-born singer-songwriter and Khalifa will take to the Grammys stage on Sunday (February 10) to perform their hit 'Adorn', which is up for three awards.
Speaking to MTV News, Miguel hinted that his fans can expect a memorable performance on the music industry's biggest night.
"It's gonna be different; expect it to be different," he teased, adding: "I can't tell you [specifics]; I don't want to spoil the moment, but it's going to be a lot of fun."
Miguel added that it's an honour for him to share the Grammy Awards stage with Khalifa, an artist who he truly admires.
"I think the illest thing about Wiz Khalifa is how true to himself he's always been, and I miss that from artists. Nothing about what he does ever felt like he was reaching to be something that he wasn't," the musician explained.
Sunday's ceremony will also feature Sting, Rihanna and Bruno Mars collaborating, in addition to performances by Sir Elton John and Ed Sheeran, Alicia Keys and Taylor Swift.
CBS will air the 2013 Grammy Awards - hosted by LL Cool J - on Sunday (February 10).
Watch Wiz Khalifa and Miguel perform 'Adorn' below: