Kicking off at 8pm ET/PT (1am GMT), the ceremony promises performances from Kelly Clarkson, Alicia Keys and Maroon 5, Rihanna and Justin Timberlake, to name but a few.
British nominees include Ed Sheeran, Florence + the Machine and Coldplay, with Adele hoping to add to her collection of six trophies won at the 2012 awards.
The Black Keys, fun., Frank Ocean, Mumford & Sons and Jack White will also be battling it out to emerge victorious in the 'Album of the Year' category, while Gotye and Taylor Swift are some of those competing for the honour of 'Record of the Year'.
> Grammy Awards 2013: The major nominees
Presenters of the awards will include Beyoncé, Carly Rae Jepsen, Katy Perry, Jennifer Lopez, Ellen DeGeneres, Ryan Seacrest and Prince.
Watch a live stream of the 2013 Grammy Awards red carpet below: