The DJs will play alongside newly announced acts Foals and Phoenix at the Scottish music festival, which takes place from July 11 to July 14.
Kendrick Lamar and BBC Sound of 2013 winners Haim will also perform at the event, which is celebrating its 20th year.
Previously announced acts who will play T in the Park include Rihanna, The Killers, Mumford & Sons, Azealia Banks and Paloma Faith.
Emeli Sandé, Kraftwerk, The Script, Two Door Cinema Club, Of Monsters and Men and Chase & Status will also take to the stage over the weekend.
Tickets for the festival go on sale on Friday, February 22. More details can be found on the T in the Park website.
Watch Calvin Harris's video for 'Sweet Nothing' featuring Florence Welch below: