The band will premiere new cut 'Sacrilege' on Zane Lowe's BBC Radio 1 show in the UK between 7pm and 9pm on Monday, February 25.
The track will serve as the lead single from Yeah Yeah Yeahs' upcoming album Mosquito, which is released on April 15.
The album is the band's fourth studio record and has been produced by Dave Sitek of TV on the Radio, who worked on the band's 2003 debut Yeah Yeah Yeahs.
Karen O recently revealed that recording the project was "a roller coaster" of emotions and that they went through some "dark times".
Yeah Yeah Yeahs will support Mosquito with a headline tour of the UK in May.
Watch a teaser for Mosquito below: