The Prodigy play their only UK performance of the year on the North Stage on Saturday, August 24, and the same stage is headlined by Guetta on Sunday, August 25.
Other acts booked over the weekend include Groove Armada, A-Trak, Sub Focus, Afrojack, Paul van Dyk, Richie Hawtin, Seth Troxler, Zane Lowe, Pete Tong, Paul Oakenfold, Annie Mac, AlunaGeorge, Eric Prydz, Adam Beyer, Skream and Benga, and Andy C, among others.
The festival takes place in Danesbury, Cheshire and runs from August 23 to August 25.
Earlybird tickets are on sale now for the weekend, with day tickets also available.
Last year, the final day of Creamfields was cancelled after heavy rain caused flooding, but a new drainage system has been installed to prevent a recurrence.
Watch footage from Creamfields 2010 below: