They will play the Scottish music event this summer, when it returns to Kinross over the weekend July 12-14.
Lawson, James Arthur, Diana Vickers, Lucy Spraggan and Bo Bruce will also play sets across the three-day festival.
Mumford & Sons, Rihanna and The Killers will headline the event, with further performances from The Script, Calvin Harris, David Guetta, Emeli Sandé, Snoop Dogg, Dizzee Rascal, Rita Ora, Jake Bugg, Paloma Faith and Labrinth.
My Bloody Valentine will play a special set at the festival, with organisers predicting that the band's performance will be "a very special moment at the festival's 20th year celebrations".
Weekend tickets with camping are on sale now for £194, while day tickets are also available.
Watch the music video for Little Mix's new single 'How Ya Doin?' below: