The track - taken from her upcoming self-titled album - features her husband and Nickelback star Chad Kroeger. Listen below:
It is the third cut from Lavigne's fifth album, which will be released in the UK on November 4 and in the US a day later.
'Let Me Go' will be available to download on the US iTunes store from October 15.
Lavigne has co-produced the new album with Martin Johnson, David Hodges and Kroeger.
The record - which was pushed back from its original September release date - also features Lavigne's collaboration with Marilyn Manson.
Watch the music video for Lavigne's 'Rock N Roll' below: