The singer beat Coldplay into second place in the all-formats chart, with The Beatles in third.
She was fourth in the MP3 rankings, but topped the physical formats list ahead of The Beatles.
Adele's second album 21 topped the album chart, followed by her debut 19.
However, her Oscar-winning James Bond theme 'Skyfall' was beaten to the best-selling single title by Rage Against The Machine's 'Killing In The Name'.
The 1992 track topped the UK charts at Christmas 2009 on the back of a campaign to prevent the X Factor winner from taking the accolade.
The fastest-selling album of Amazon UK's past 15 years is One Direction's upcoming Midnight Memories.
"Adele's achievement in securing both the best-selling artist title and the top two best-selling albums of the past 15 years on Amazon.co.uk is remarkable," said head of Music at Amazon.co.uk. Paul Firth.
"The fact that Rage Against The Machine's 'Killing In The Name' has pushed Adele into second place in the best-selling singles chart is indicative of how much the UK loves a good campaign and how the public love the underdog.
"The appearance of 'Gangnam Style' at number three in the all-time singles chart perhaps shows a future in which the internet makes music tastes more international than ever before."
The Amazon.co.uk best-selling charts for the past 15 years are as follows:
Artists (All Formats)
3. The Beatles
4. Lady Gaga
6. Michael Bublé
7. Kings of Leon
8. Snow Patrol
10. Michael Jackson
Artists (Physical /Digital)
1. Adele / Lady Gaga
2. The Beatles / Rihanna
3. Coldplay / Glee Cast
4. Michael Bublé /Adele
5. Snow Patrol / Katy Perry
6. Pink Floyd / The Black Eyed Peas
7. Kings of Leon / Take That
8. Amy Winehouse / Coldplay
9. Susan Boyle / Florence + The Machine
10. Bob Dylan / Jessie J
11. U2 / Kings of Leon
12. Queen / Bruno Mars
13. Muse / Michael Jackson
14. Robbie Williams / Eminem
15. Elbow / Pixie Lott
16. Oasis / Rage Against The Machine
17. Michael Jackson / Michael Bublé
18. Rihanna / Beyoncé
19. Foo Fighters / Flo Rida
20. The Killers / Maroon 5
Best-selling Albums (all formats)
1. Adele - 21
2. Adele - 19
3. Take That - Progress
4. Susan Boyle - I Dreamed A Dream
5. Various Artists - Now That's What I Call Music! 83
6. Kings Of Leon - Only By The Night
7. Amy Winehouse - Back To Black
8. Mumford & Sons - Sigh No More
9. Various Artists - Now That's What I Call Music! 80
10. Various Artists - Now That's What I Call Music! 77
Best-selling Singles (MP3)
1. Rage Against The Machine - 'Killing In The Name' [Explicit]
2. Adele - 'Skyfall'
3. Psy - 'Gangnam Style'
4. Adele - 'Someone Like You'
5. Black Eyed Peas - 'I Gotta Feeling' (Album Version)
6. Robin Thicke - 'Blurred Lines' [feat. T.I., Pharrell]
7. Carly Rae Jepson - 'Call Me Maybe'
8. Gotye - 'Somebody That I Used To Know' [feat. Kimbra]
9. Daft Punk - 'Get Lucky' (Radio Edit)
10. James Arthur - 'Impossible'