Trivium, In Flames, While She Sleeps, Letlive, The Black Dahlia Murder, Crossfaith, Miss May I, Blessthefall and Dying Fetus will also play the event - headlined by Aerosmith, Linkin Park and Avenged Sevenfold - taking place at Donington Park between June 13-15.
The Offspring last performed at Download in 2008. Guitarist Noodles said: "It's been six years since we first played Download and we can't wait to return and rip it up. Stoked!"
Status Quo are making their debut at the festival and Francis Rossi said: "When Status Quo once again take to the Donington stage, it will have been 32 years since we headlined the Monsters of Rock Festival on August 21st 1982.
"That year saw the Falklands War, the launch of the Commodore 64, Aston Villa winning the European Cup and the raising of the Mary Rose. You might say a lot has changed since then but we are still rocking, and still playing the Quo hits. See you there."
The festival is keeping standard 2013 prices of £160 for a weekend arena ticket. Weekend tickets with three-night camping are priced at £185, with five-night camping an additional £10.
Watch the video for The Offspring's 'Pretty Fly (For A White Guy)' below: