The DJ has topped the list with his new single 'I Got U', which samples Whitney Houston's 'My Love Is Your Love'.
Route 94 are currently at number two with 'My Love', John Legend is at three with 'All of Me', DVBBS and Borgeous are at four with 'Tsunami' and Pharrell Williams is at five with 'Happy'.
Little Mix are the second highest new entry on the daily sales list, with their Sport Relief single 'Word Up!' currently at number six.
Further down, Example's 'Kids Again' is at 11, American Authors are at 32 with 'Best Day Of My Life' and X Factor singer Nicholas McDonald is at 42 with 'Answerphone'.
Over on the album chart, Kylie Minogue leads the way with her 12th studio collection Kiss Me Once.
George Michael is just behind with his new album Symphonica and Glee's Lea Michele completes the Top 3 with her debut set Louder.
Skrillex is up to five with surprise release Recess and American Authors are at six with their debut album Oh, What A Life.
Watch the music video for Duke Dumont's 'I Got U' below: