The music producer, who was recruited to work on six tracks for Kylie Minogue's comeback album earlier this year, has insisted that he chooses his projects very carefully and wants nothing to do with the girl group.
"God no, those people I would never work with," Calvin told the Daily Star. "I know they can all sing but it wouldn't be an enjoyable experience at all."
Harris added that he thinks the girls need to reinvent themselves, but he has no plans to team up and help them to do so.
"They really need to change their sound," he said. "It's getting extremely boring now - but it's not for me."