Music
The rap mogul retired from making music when he signed a three-year contract for the position in 2005.
It was recently reported that he faced being dropped from the label because of his "excessive" payment demands.
However, he has now revealed that he is leaving to pursue “new challenges”, saying in a statement: "I am pleased to have had the opportunity to build upon the Def Jam legacy, helping to move the company into a new era of artistic success."
Andy 'L.A.' Reid, Island Def Jam Music Group chairman and CEO, said: "While he will continue to be one of our signature artists, he will nonetheless be missed in this executive capacity.”
Jay-Z has signed artists including Rihanna and Ne Yo to the label.
> Jay-Z denies secret wedding
More: Music
Singles Reviews
Gym Class Heroes ft. Neon Hitch: 'Ass Back Home' reviewThe group are whipped into shape on their latest effort.
The Sound
Ones to watch: LawsonDigital Spy finds out more about the fast-rising group.
Music Interviews
Cher Lloyd: 'LA Reid loves scrambled eggs'Digital Spy finds out what the singer has been up to in America.
Album Reviews
The Ting Tings: 'Sounds From Nowheresville' reviewThe duo overcomplicate matters on their second studio album.
