It becomes the first song to spend that long at number one since Beyoncé's 'Irreplaceable' enjoyed a ten-week reign at the summit from December 2006.
Chris Brown's 'With You' holds steady at two, while Rihanna's 'Don't Stop The Music' sticks at three.
Elsewhere, Jordin Sparks's duet with Chris Brown, 'No Air', vaults from 23 to 13, while Mariah Carey's 'Touch My Body' leaps from 57 to 34, becoming the singer's 31st US top 40 hit.
1. (1) Flo Rida ft. T-Pain: 'Low'
2. (2) Chris Brown: 'With You'
3. (3) Rihanna: 'Don't Stop The Music'
4. (5) Sara Bareilles: 'Love Song'
5. (4) Alicia Keys: 'No One'
6. (6) Timbaland ft. OneRepublic: 'Apologise'
7. (7) Snoop Dogg: 'Sensual Seduction'
8. (8) Sean Kingston: 'Take You There'
9. (10) Webbie, Lil' Phat & Lil' Boosie: 'Independent'
10. (9) Buckcherry: 'Sorry'