The singer is expected to perform 'Run For Your Life' during the first results show of The X Factor next month.
However, Cardle confessed that he is anxious about playing the song to Barlow as the Take That star and current X Factor judge is the track's main songwriter.
When asked by the PunchBowl Blog if he'd be performing on The X Factor, Cardle replied: "I think so. It's not 100% yet, but I hope so.
"I will be crapping my pants once again on that show, but I will be with my band and singing something I really feel."
He added: "I thought it would be great because Simon [Cowell] won't be there and he won't be judging me with his hawk eye, but Gary wrote that track and I want to sing it with the conviction it deserves."
Matt Cardle's first single proper 'Run For Your Life' will be available to download on October 9, while his new album Letters is released on October 17.
> Matt Cardle: 'One Direction shouldn't have released single before me'
Watch the full interview with Matt Cardle below: