The singer described the 'Cannonball' group - comprising Jesy Nelson, Jade Thirlwall, Perrie Edwards and Leigh-Anne Pinnock - as "absolutely adorable" and suggested that they had recaptured her former band's "really fun" side.
"I love them," she said during an appearance on Lorraine. "What I love about these girls is they've got fantastic voices, they're really talented, but they look like young girls. They're not uber sexy, uber glam, they're really good positive role models, which we don't have that many of.
"They remind me of the Spice Girls in that way, because they're really fun and young and I think that's what pop music should be about. It's kind of got a bit too serious and a little bit too sexy at times."
However, Mel C warned Little Mix not to take their fame for granted.
"My advice to them would be enjoy it, enjoy every minute, because it doesn't last forever," she said. "When you're in the middle of it, you don't think of the future.
"You get so busy and you can get weighed down with the all pressures - just enjoy it. It's a fairytale, it's a dream come true for so many young girls."
Mel C also confirmed this morning that the Spice Girls will not reunite for the Queen's Diamond Jubilee.
Speaking to Digital Spy while competing on The X Factor last year, Little Mix said that they would like to become "a modern day Spice Girls".
"The Spice Girls all had individual personalities and girls can relate to a different one," Edwards said. "I think they were approachable as a girl group and you wanted to be their friends. That's what we want to go for."
Watch Little Mix in the video for 'Cannonball' below: