The online entertainment store confirmed that the album, which is scheduled for release on November 23, has exceeded the previous record set by Japanese rock group Mr Children's Supermarket Fantasy in 2008.
"Just eight months ago, no-one was aware of the talents of Susan Boyle. Now, she has generated more Amazon pre-order CD sales globally than any other artist," Julian Monaghan said.
"That is an incredible achievement and is testament to the fact that she has captured the hearts of people all over Britain, America and the rest of the world."
Columbia Records Chairman Steve Barnett added: "One of the things that is so unique about Susan Boyle is her ability to touch people around the world. We're excited that I Dreamed A Dream holds the new record for global pre-orders and that Amazon's customers have supported her album in this way."
Japanese popstar Ken Hirai's 10th Anniversary Complete Single Collection, '95-'05 is the third most popular pre-order ever on the site.
Norah Jones album Not Too Late is in fourth position and Take That's 2008 greatest hits Never Forget: The Ultimate Collection is fifth most popular ever.